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Measures of Exposure (Biomonitoring)

Nicotine biomarkers nicotine biomonitoring nicotine measures of exposure
Nicotine and Nicotine Related Metabolites:    
    Nicotine     Matrices – Serum, Plasma, Saliva, Urine
    Cotinine     Matrices – Serum, Plasma, Saliva, Urine
    trans-3-Hydroxycotinine     Matrices – Saliva, Urine
    Cotinine-N-b-D-glucuronide     Matrix – Urine
    Nicotine-N-b-glucuronide     Matrix – Urine
    trans-3-Hydroxycotinine-O-b-D-glucuronide     Matrix – Urine
Aromatic Amines:    
    1-Aminonaphtalene     Matrix – Urine
    2-Aminonaphtalene     Matrix – Urine
    3 and 4 Aminobiphenyl     Matrix – Urine
    o-Toluidine     Matrix – Urine
Acrolein:    
    3-Hydroxypropyl mercapturic acid(3-HPMA)     Matrix – Urine
1,3 – butadiene:    
    Monohydroxybutenyl mercapturic acid(MHBMA)     Matrix – Urine
    Dihydroxylbutyl mercapturic acid(DHBMA)     Matrix – Urine
Benzene:    
    S-Phenyl mercapturic acid(SPMA)     Matrix – Urine
Caffeine     Matrices – Serum, Plasma, Saliva, Urine
Crotonaldehyde:    
    3-hydroxy-1methylpropylmercapturic acid     Matrix – Urine
Tobacco Specific Nitrosamines:    
    NAB and BAB-N-glucuronide*     Matrix – Urine
    NAT and NAT-N-glucuronide*     Matrix – Urine
    NNN and NNN-N-glucuronide*     Matrix – Urine
    NNK and NNK-N-glucuronide*     Matrix – Urine
    (*Total TSNA and corresponding N-glucuronide)    
NNK:    
    NNAL and Conjugated glucuronides     Matrix – Urine
Polycyclic Aromatic Hydrocarbons:    
    1-Hydroxypyrene(1-HOP)     Matrix – Urine
Free Radicals:    
    8-hydroxy-2'-deoxyguanosine(8-OHdG)     Matrix – Urine
Urine Mutagenicity    
Yield in Use (Filter Nicotine)    

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